Researchers from India and the United States are collaborating to create an optogenetic tool to better understand brain disorders.

Indian researchers from Jamia Millia Islamia cooperated with the National Institutes of Health in the United States to create a tool to better comprehend brain illnesses.

The instrument can assist in the understanding of Alzheimer's illness, depression, and schizophrenia.
The instrument can assist in the understanding of Alzheimer’s illness, depression, and schizophrenia.

Researchers from Jamia Millia Islamia (JMI) in partnership with the National Institutes of Health (NIH) in the United States have created an optogenetic tool that can aid in the understanding of brain illnesses such as Alzheimer’s disease, depression, and schizophrenia.

According to the JMI, the instrument can examine molecular trafficking in neurons and was created by Dr Tanveer Ahmad, who completed his postdoctoral studies at the NIH before joining the varsity’s Multidisciplinary Centre for Advanced Research and Studies (MCARS) as an assistant professor.

“Understanding the molecular intricacies of these disorders will aid in the development of tailored medicines, particularly viral and mRNA-based techniques that are unique to a certain target molecule in the cells,” Ahmad added.

According to him, the technology may be used to investigate other biological concerns such as memory formation and the creation of inducible light-activated treatments for the treatment of cancer and dementia.

Using the potential of phototropic receptors known as light-oxygen-voltage-sensing domains (AsLOV2) produced from the plant Avena Sativa (oats), the researchers created novel chimeric molecular designs by conjugating a light-sensitive domain of LOV2 with a protein called neuregulin3 (NRG3).

According to the statement, Alzheimer’s, schizophrenia, and depression all have genetic variants in NRG3, making it a sensitive gene for these disorders.

The researchers found a novel process of protein trafficking in hippocampal neurons of the brain using this revolutionary technology, which they dubbed “trans-synaptic retention,” according to the study.

According to Professor Mohd. Zulfequar, Director of MCARS, these unique futuristic optogenetic techniques will make it easier than ever to comprehend human illnesses and create creative therapeutic options.

The optogenetic technology has transformed the area of neuroscience, and partnership with international organizations such as the NIH demonstrates that India is at the forefront of developing and implementing these cutting-edge technologies, he added.

According to the JMI, a study in this area was published in the highly regarded peer-reviewed scientific magazine “Journal of Cell Biology” by The Rockefeller University in the United States.

According to the paper, Ahmad is the primary author, with Rituparna Chaudhuri and Nisha Chaudhary also contributing.

Dr. Andres Buonanno is the principal author, and co-authors include Dr. Detlef Vullhorst, Dr. Carlos Guardia, Dr. Irina Karavanova, and Dr. Juan Bonifacino.

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